Lundbeck hopes to find a validated method to diagnose Parkinson’s disease. The method is based on a biomarker and can potentially lead to earlier diagnosis of patients. Today, there is no single test that can diagnose Parkinson’s disease, and success could mean better outcomes for people with Parkinson’s disease.
H. Lundbeck A/S (Lundbeck) will begin research on a novel method for earlier and more precise diagnosis of Parkinson’s disease, the likes of which do not currently exist. By diagnosing Parkinson’s disease as early as possible, patients can benefit from a greater choice in treatment options. This research is funded by The Michael J. Fox Foundation for Parkinson’s Research (MJFF).
The project is pre-competitive, meaning that the results derived from the research will be shared with the pharmaceutical industry, academia and made public by MJFF.
“We are pleased to receive this grant from The Michael J. Fox Foundation. We still see a great unmet medical need in Parkinson’s disease today, and hopefully this research can help diagnose the disease earlier and thereby improve the outcomes for the patients,” says Johan Luthman, Executive Vice President for Research & Development at Lundbeck.
The research project will develop and validate a test to diagnose Parkinson’s disease using the cerebrospinal fluid (CSF) which flows in and around the brain and spinal cord. Such a test is known as a biomarker assay, a clinical tool that can measure different substances in the human body. This novel assay aims to measure alpha-synuclein, a protein believed to cause Parkinson’s disease, in the CSF and by doing so aids in an earlier and more precise Parkinson’s diagnosis.
Misdiagnosis of Parkinson’s disease is a common problem. One study found that almost 20% of people diagnosed with Parkinson’s disease suffers from a different disease with similar symptoms.
“A biological marker of Parkinson’s disease would transform patient care and research, allowing earlier and more accurate diagnosis and more efficient therapeutic testing. Aggregated alpha-synuclein is a leading biomarker candidate, and our Foundation is pleased to support Lundbeck toward measurements of this pathological protein,” says Luis Oliveira, PhD, Associate Director of Research Programs at The Michael J. Fox Foundation.
A well-established partnership within Parkinson’s disease research
This is the fifth time in twelve years that MJFF is funding a research program driven by Lundbeck. Previously, the foundation has supported Lundbeck in research on antibodies, in understanding the Lrrk2 gene and in exploration of two potential new targets for treating Parkinson’s disease. All four projects have the potential to bring new drug targets and treatments to people living with Parkinson’s disease. This recent grant supports the research efforts with 1.3 million DKK.
Lundbeck also supports MJFF efforts. The company is member of three groups organized by the MJFF: Parkinson Progression Markers Initiative (PPMI), the Research Tools Consortium for Industry (ITC) and the Parkinson’s Disease Education Consortium (PDEC), an alliance of biotechnology and pharmaceutical firms that support work to furnish high-quality education resources for the Parkinson’s community.
“We are proud to work with The Michael J. Fox Foundation. It is one of the most ambitious NGOs working for a better future for people living with Parkinson’s disease, and we truly believe that the foundation brings hope,” says Johan Luthman.
|Mikkel Ballegaard Pedersen||Mads Kronborg|
|Journalist, Corp. Communication||Senior Director, Corp. Communication|
|+45 30 83 20 44||+45 36 43 40 00|
H. Lundbeck A/S (LUN.CO, LUN DC, HLUYY) is a global pharmaceutical company specialized in brain diseases. For more than 70 years, we have been at the forefront of neuroscience research. We are tirelessly dedicated to restoring brain health, so every person can be their best.
An estimated 700 million people worldwide are living with brain diseases and far too many suffer due to inadequate treatment, discrimination, a reduced number of working days, early retirement and other unnecessary consequences. Every day, we strive for improved treatment and a better life for people living with brain diseases – we call this Progress in Mind.
Read more at www.lundbeck.com/global/about-us/progress-in-mind.
Our approximately 5,800 employees in more than 50 countries are engaged in the entire value chain throughout research, development, production, marketing and sales. Our pipeline consists of several R&D programs and our products are available in more than 100 countries. We have research centres in Denmark and the US and our production facilities are located in Denmark, France and Italy. Lundbeck generated revenue of DKK 17.0 billion in 2019 (EUR 2.3 billion; USD 2.6 billion).
 Rizzo, Giovanni et. Al. “Accuracy of Clinical Diagnosis of Parkinson Disease: A Systematic Review and Meta-Analysis Neurology, 86 (6), 566-76, 2016 Feb 9
H. Lundbeck A/S
Ottiliavej 9, 2500 Valby, Denmark
+45 3630 1311